【佳學(xué)基因檢測(cè)】維生素 D 狀態(tài)和 VDR 多態(tài)性基因檢測(cè)預(yù)測(cè)分化型甲狀腺癌的治療效果

腫瘤基因檢測(cè)的費(fèi)用大概多少錢引言

研究癌癥的早期發(fā)現(xiàn)及檢測(cè)獲悉《In Vivo》在. 2022 Sep-Oct;36(5):2434-2441.發(fā)表了一篇題目為《維生素 D 狀態(tài)和 VDR 多態(tài)性基因檢測(cè)預(yù)測(cè)分化型甲狀腺癌的治療效果》腫瘤靶向藥物治療基因檢測(cè)臨床研究文章。該研究由Andra-Maria Cocolos, Andrei Muresan, Andra Caragheorgheopol, Mircea Ghemigian, Dumitru Ioachim, Catalina Poiana等完成。促進(jìn)了腫瘤的正確治療與個(gè)性化用藥的發(fā)展，進(jìn)一步強(qiáng)調(diào)了基因信息檢測(cè)與分析的重要性。

腫瘤靶向藥物及正確治療臨床研究?jī)?nèi)容關(guān)鍵詞：

25OH維生素D,FokI,甲狀腺癌, VDR 多態(tài)性,維生素D

腫瘤靶向治療基因檢測(cè)臨床應(yīng)用結(jié)果

甲狀腺癌治療效果基因檢測(cè)的背景/目的：維生素 D 缺乏和維生素 D 受體 (VDR) 基因多態(tài)性參與多種生物學(xué)過程，包括惡性腫瘤中的細(xì)胞增殖、凋亡和粘附。甲狀腺癌治療效果基因檢測(cè)研究調(diào)查了維生素 D 水平和 VDR 的基因序列差異性是否是甲狀腺癌的危險(xiǎn)因素。同時(shí)測(cè)量了 VDR 基因多態(tài)性（ApaI、TaqI、FokI 和 BsmI）及其 25(OH)D 水平。還獲得了所有患者的大人群統(tǒng)計(jì)學(xué)數(shù)據(jù)和組織病理學(xué)報(bào)告。甲狀腺癌治療效果基因檢測(cè)的結(jié)果：甲狀腺癌組的維生素 D 水平顯著降低 (p=0.03)。 FokI 和 TaqI 多態(tài)性在甲狀腺癌患者基因檢測(cè)結(jié)果中更為常見（p<0.001）。與對(duì)照組相比，甲狀腺癌患者中 FokI Ff 基因型的比例增加（p<0.0006），TaqI Tt 基因型的比例也更高（p<0.0001）。 FokI的Ff基因型也與多灶性甲狀腺癌、侵襲模式和局部轉(zhuǎn)移風(fēng)險(xiǎn)相關(guān)。甲狀腺癌治療效果基因檢測(cè)的結(jié)論：VDR基因FokI的多態(tài)性基因檢測(cè)可能與甲狀腺癌及其更具侵襲性的風(fēng)險(xiǎn)相關(guān)。關(guān)鍵詞：25OH維生素D；FokI；甲狀腺癌; VDR 多態(tài)性；維生素D。

腫瘤發(fā)生與反復(fù)轉(zhuǎn)移國(guó)際數(shù)據(jù)庫(kù)描述：

Background/aim: Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms are involved in a variety of biological processes including cell proliferation, apoptosis, and adhesion in malignant tumors. This study investigated whether vitamin D levels and genetic variations of VDR are risk factors for thyroid cancer.Patients and methods: Patients who underwent surgery for differentiated thyroid carcinoma (n=113) and those with benign thyroid pathology (n=150) were genotyped for VDR gene polymorphisms (ApaI, TaqI, FokI, and BsmI) and their 25(OH)D levels were simultaneously measured. Demographic data and histopathologic reports were also acquired for all patients.Results: Vitamin D levels were significantly lower in the thyroid cancer group (p=0.03). FokI and TaqI polymorphisms were more frequent in the thyroid cancer patients (p<0.001). Compared to control, the proportion of the FokI Ff genotype was increased (p<0.0006) and the proportion of the TaqI Tt genotype was also higher among patients with thyroid cancer (p<0.0001). The Ff genotype of FokI was also associated with multifocality, invasive pattern, and risk for local metastasis.Conclusion: The VDR gene polymorphism FokI may be associated with the risk of thyroid cancer and its more aggressive forms.Keywords: 25OHvitamin D; FokI; Thyroid cancer; VDR polymorphisms; vitamin D.